Research Title: Effect of Nonsurgical Periodontal Therapy on Salivary Interleukin-8 Levels in Patients with Chronic Periodontitis
Author: Haween T. Nanakaly, Hozan Wrya Azeez and Solav M. Abdul-Qadir
Abstract: Cytokines play an important role in the pathogenesis of inflammatory disease, including chronic periodontitis (CP). Because of pro-inflammatory and neutrophil chemotactic properties of Interleukin-8 (IL-8), the IL-8 may play a significant role in the pathogenesis of periodontitis.
Aim: This study was done to estimate and compare salivary levels of IL-8 in periodontal health and disease, and also to assess the effect of non-surgical periodontal therapy on its levels in chronic periodontitis patients, in relation to clinical parameters.
Materials and Methods: Thirty chronic periodontitis patients and 30 healthy controls were recruited for the study. The periodontal status was assessed by gingival index(GI), Probing pocket depth (PPD), Bleeding on probing (BOP) and Clinical attachment level (CAL). The level of IL-8 in salivary fluid was measured by enzyme-linked immunosorbent assay kit. Non-surgical periodontal therapy (Scaling and root planning; SRP) was performed on chronic periodontitis patients and a follow-up was done after 4 weeks.
Results: The level of IL-8 in saliva of periodontitis patients was significantly higher (p< 0.001) compared to healthy controls at baseline. SRP therapy improved all clinical parameters and salivary IL-8 levels in periodontitis patients. A significant correlation was observed between CAL and IL-8(r=0.312, p= 0.052), BOP and IL-8 (r=0.332, p=0.050) before therapy, and BOP and IL-8 (r=0.373,p=0.04) after therapy.
Conclusion: These data suggest that levels of salivary IL-8 generally decrease after nonsurgical periodontal therapy. Correlation between some clinical periodontal parameters and level of salivary IL-8 was found.
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Proceeding Book of ICASEE
5th year , 7 – 9th April, 2018